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AG "Bakterielle Physiologie und Biochemie" (Prof. Dr. H. Jung)

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Prof. Dr. Heinrich Jung

Prof. Dr. Jung, Heinrich

Telefon: +49 (0)89 / 2180-74630

E-Mail: hjung@lmu.de

  • Role of the RND and ABC efflux systems in siderophore secretion in Pseudomonas putida and other gamma-proteobacteria

    Iron is essential for life since it is required for electron transfer processes and acts as a cofactor of various enzymes involved in central metabolism and detoxification of reactive oxygen species. For this reason, several species of bacteria secrete siderophores, molecules that sequester iron in order to cope with iron starvation. We use Pseudomonas putida as a model to study the molecular basis of siderophore production. P. putida is a Gram-negative soil bacterium that colonizes the rhizosphere of plants and produces a fluorescent siderophore called pyoverdine. mehr

  • Structure and function of SSSF-related sensor kinases in Pseudomonas

    pp

    Pseudomonas putida is a soil bacterium and colonizes the root system of plants. Establishment and maintenance of contacts of the cell with other organisms require transmembrane signal transduction. In this context, we are studying a new type of putative sensor kinase/response regulator (SK/RR) systems of P. putida that is characterized by a sensor kinase containing a N-terminal domain similar to members of the sodium/solute symporter family (SSSF, e.g., PutP, PanF) at the primary and secondary structure level, and a C-terminal domain sharing homology to histidine kinases (e.g., NtrB). Research is focused on the SK/RR-system CbrA/CbrB (PP4695/PP4696) of P. putida KT2440 that is involved in C-source utilization. mehr

  • Maintenance and evolution of cooperation in synthetic microbial ecosystems

    The project focusses on a qualitative and quantitative understanding of cooperative interactions in synthetic microbial ecosystems and its effect on population heterogeneity. Experimental studies are combined with mathematical models.We are aiming at understanding the emergence and maintenance of “social” behavior in bacterial populations where phenotypic heterogeneity is subject to selection mechanisms associated with competition between different strains and due to population. mehr

  • Role of L-proline for the human pathogen H. pylori

  • Structure and function of the sodium/proline symporter PutP

    Teaser2

    The sodium/proline transporter PutP is a member of the sodium/solute symporter (SSS) family (TC 2A.21, SLC5), which contains more than 1000 proteins of pro- and eukaryotic origin. Within the family, the capability of proline uptake is restricted to proteins of bacteria and archaea. Here, proline uptake via PutP may contribute to: i. the use of proline as source of carbon, nitrogen and energy; ii. the supply of cells with compatible solute during adaptation to osmotic stress; or iii. the modulation of the intracellular redox environment and scavenging of reactive oxygen species. Based on these functions, PutP can be of significance for bacteria-host interactions including the virulence of pathogens like as Helicobacter pylori, Staphylococcus aureus and others. mehr

  • Transport and metabolism of L-carnitine in enterobacteria

  • Publications

  • Team

  • Topics for Bachelor and Master Theses