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Bracher, S., Guérin, K., Polyhach, Y., Jeschke, G., Dittmer, S., Frey, S., Böhm, M. and Jung, H. (2016)  Core Transmembrane Domain 6 Plays a Pivotal Role in the Transport Cycle of the Sodium/Proline Symporter PutP. J. Biol. Chem. 291, 26208-26215.   doi: 10.1074/jbc.M116.753103

Bracher, S., Guérin, K., Polyhach, Y., Jeschke, G., Dittmer, S., Frey, S., Böhm, M. and Jung, H. (2016) Glu311 in external loop 4 of the sodium/proline transporter PutP is crucial for external gate closure. J. Biol. Chem. 291, 4998-5008. doi: 10.1074/jbc.M115.675306

Wienand, K., Lechner, M., Becker, F., Jung, H., and Frey, E. (2015) Non-selective evolution of growing populations. PLOS ONE , e0134300. doi: 10.1371/journal.pone.0134300

Li, Z., Lee, A.S.E., Bracher, S., Jung, H., Paz, A., Kumar, J.P., Abramson, J., Quick, M. and Shi, L. (2015) Identification of a second substrate binding site in solute:sodium symporters. J. Biol. Chem. 290, 127-141doi: 10.1074/jbc.M114.58438

Raba, M.a, Dunkel, S.a,  Hilger, D., Lipiszko, K., Polyhach, Y., Jeschke, G., Bracher, S., Klare, J.P., Quick, M., Jung, H.* and Steinhoff, H.-J.* (2014) Extracellular loop 4 of the proline transporter PutP controls the periplasmic entrance to ligand binding sites. Structure 22, 769-780. doi: 10.1016/j.str.2014.03.011.

aThese authors contributed equally; *Shared corresponding authorship

Rivera Ordaz, A., Bracher, S., Sarrach, S., Li, Z., Shi, L., Quick, M., Hilger, D., Haas R. and Jung, H. (2013) The sodium/proline transporter PutP of Helicobacter pylori. PLOS ONE 8, e83576. doi: 10.1371/journal.pone.0083576

Stengel, A., Gügel, I.L., Hilger, D., Rengstl, B., Jung, H.,and  Nickelsen, N. (2012) Initial steps in photosystem II de novo assembly and preloading with manganese take place in biogenesis centers in Synechocystis. Plant Cell 24, 660-674. 

Jung, H., Hilger, D. and Raba, M. (2012) The  Na+/proline transporter PutP. Front. Biosci. 17, 745-59. (Review)

Olkhova, E.a, Raba, M.a, Bracher, S., Hilger, D. and Jung, H. (2011) Homology model of the Na+/proline transporter PutP of Escherichia coli and its functional implications. J. Mol. Biol. 406, 59-74.

aThese authors contributed equally

Hilger, D. and Jung, H. (2010) Protein chemical and EPR spectroscopic approaches to monitor membrane protein structure and dynamics. in Bacterial signaling (Krämer, R. and Jung, K., Eds.), Wiley-VCH, Weinheim, pp. 247-263. (Book chapter)

Jung, K. and Jung, H. (2009) A New mechanism of phospho-regulation in signal transduction pathways. Science Signaling, 2, pe71.

Hilger, D., Polyhach, Y., Jung, H. and Jeschke, G. (2009) Backbone structure of transmembrane domain IX of the Na+/proline transporter PutP of Escherichia coli. Biophys. J., 96, 217-225.

Raba, M., Baumgartner, T., Hilger, D., Klempahn, K., Härtel, T., Jung, K. and Jung, H. (2008) Function of transmembrane domain IX in the Na+/proline transporter PutP. J. Mol. Biol., 382, 884-893.

Hilger, D., Böhm, M., Hackmann, A. and Jung, H. (2008) Role of Ser340 and Thr341 in transmembrane domain IX of the Na+/proline transporter PutP of Escherichia coli in ligand binding and transport. J. Biol. Chem., 283, 4921-4929.

Hilger, D., Polyhach, Y., Padan, E., Jung, H. and Jeschke, G. (2007) High-resolution structure of a Na+/H+antiporter dimer obtained by pulsed electron paramagnetic resonance distance measurements. Biophys. J., 93, 3675-3683.

Weber-Sparenberg, C., Pöplau, P., Brookman, H., Rochon, M., Möckel, C., Nietschke, M., Jung H (2006) Characterization of the type III export signal of the flagellar hook scaffolding protein FlgD of Escherichia coli. Arch Microbiol 186, 307-316

Jung, H., Pirch, P. and Hilger, D. (2006) Secondary transport of amino acids in prokaryotes. J. Membr. Biol., 213, 119-133. doi: 10.1007/s00232-006-0880-x (Review)

Jeschke, G., Chechik, V., Ionita, P., Godt, A., Zimmermann, H., Banham, J., Timmel, C.R., Hilger, D. and Jung, H. (2006) DeerAnalysis2006 - A Comprehensive Software Package for Analyzing Pulsed ELDOR Data. Appl. Magn. Res.,30, 473-489.

Hilger, D., Jung, H., Padan, E., Wegener, C., Vogel, K.-P., Steinhoff, H.-J. and Jeschke, G. (2005) Assessing Oligomerization of Membrane Proteins by Four-Pulse DEER: pH-dependent Dimerization of NhaA Na+/H+ antiporter of E. coli. Biophys. J., 89, 1328-1338.

Vinothkumar, K.R., Raunser, S, Jung, H. and Kuehlbrandt, W. (2006) Oligomeric structure of the carnitine transporter CaiT from Escherichia coli, J. Biol. Chem. 281, 4795-4801

Zhou, A., Wozniak, A., Meyer-Lipp, K., Nietschke, M., Jung H., Fendler, K. (2004) Charge Translocation During Cosubstrate Binding in the Na+/Proline Transporter of E. coli. J. Mol. Biol. 343, 931-942.

Jeschke, G., Wegener, C., Nietschke, M., Jung, H., and Steinhoff, H.-J. (2004) Distance Determination by Four-Pulsed DEER in an Integral Membrane Protein, the Na+/Proline Transporter PutP of Escherichia coli. Biophys. J.. 86, 2551-2557.

Pirch, T., Landmeier, S., and Jung, H. (2003) Transmembrane domain II of the Na+/proline transporter PutP of Escherichia coli forms part of a conformationally flexible, cytoplasmic exposed aqueous cavity within the Membrane. J. Biol. Chem. 278, 42942-42949.

Pirch, T., Nietschke, M., Landmeier, S., Quick, M. and Jung, H. (2002) Sites important for Na+ and substrate binding in the Na+/proline transporter of Escherichia coli, a member of the Na+/solute symporter family, J. Biol. Chem. 277, 8790-8796.

Jung, H. (2002) The sodium/substrate symporter family: structural and functional features. FEBS Lett. 529, 73-77. doi: 10.1016/S0014-5793(02)03184-8 (Review)

Jung, H. (2001) Sodium/substrate transport. in Microbial Transport Systems (G. Winkelmann, Ed.) pp. 47-75, Wiley-VCH, Weinheim. (Book chapter)

Jung, H. (2001) Towards the molecular mechanism of Na+/solute symport in prokaryotes. Biochim. Biophys. Acta 1505, 131-143. (Review)

Wegener, C., Tebbe, S., Steinhoff, H.-J. and Jung, H. (2000) Spin Labeling Analysis of Structure and Dynamics of the Na+/Proline Transporter of Escherichia coli. Biochemistry 39, 4831-4837.

Jung, H. (2000) Properties and mechanism of the Na+/proline transporter of Escherichia coli, a member of the Na+/solute symporter family. Recent Research Developments in Biochemistry 2, 147-157. (Review)

Jung, H. (2000) Na+/Substrat-Symport: auf dem Weg zum molekularen Mechanismus. Biospektrum 6, 196-198. (Review)

Rübenhagen, R. Rönsch, H., Jung, H., Krämer, R. and Morbach, S. (2000) Osmosensor and osmoregulator properties of the betaine carrier BetP from Corynebacterium glutamicum in proteoliposomes. J. Biol. Chem. 275, 735-741.

Quick, M., Stölting, S. and Jung, H. (1999) Role of conserved Arg40 and Arg117 in the Na+/Proline transporter of Escherichia coli. Biochemistry 38, 13523-13529.

Racher, K.I., Voegele, R.T., Marshall, E.V., Culham, D.E., Wood, J.M., Jung, H., Bacon, M., Cairns, M.T., Ferguson, S.M., Liang, W-J., Henderson, P.J.F., White, G. and Hallett, F.R. (1999) Purification and reconstitution of an osmosensor: transporter ProP of Escherichia coli senses and responds to osmotic shifts. Biochemistry 38, 1676- 1684.

Jung, H., Ruebenhagen, R., Tebbe, S., Leifker, K., Tholema, N., Quick, M. and Schmid, R. (1998) Topology of the Na+/proline transporter of Escherichia coli. J. Biol. Chem. 273, 26400-26407.

Jung, H., Tebbe, S., Schmid, R and Jung, K. (1998) Unidirectional reconstitution and characterization of purified Na+/proline transporter of Escherichia coli. Biochemistry 37, 11083-11088.

Jung, H. (1998) Topology and function of the Na+/proline transporter of Escherichia coli, a member of the Na+/solute cotransporter family. Biochim. Biophys. Acta 1365, 60-64. (Review)

Quick, M. and Jung, H. (1998) A conserved aspartate residues, Asp187, is important for Na+-dependent proline binding to the Na+/proline transporter of Escherichia coli. Biochemistry 37, 13800-13806.

Quick, M. and Jung, H. (1997) Aspartate 55 in the Na+/proline permease of Escherichia coli is essential for Na+ coupled proline uptake. Biochemistry 36, 4631-4636.

Quick, M., Tebbe, S. and Jung, H. (1996) Ser57 in the Na+/proline permease of Escherichia coli is critical for high-affinity proline uptake. Eur. J. Biochem. 239, 732-736.

Consler, T., Persson, B., Jung, H., Zen, K., Jung, K., Verner, G., Prive, G.G. and Kaback, H.R. (1993) Properties and purification of an active biotinylated lactose permease from Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 90, 6934-6938.

Jung, K., Jung, H., Colacurcio, P. and Kaback, H.R. (1995) Role of glycine residues in the structure and function of lactose permease, an Escherichia coli membrane transport protein. Biochemistry 34, 1030-1039.

Kaback, H.R., Jung, K., Jung, H., Wu, J., Privé, G.G. and Zen, K. (1995) Helix packing in the C-terminal half of lactose permease. in Advances in Cell and Molecular Biology of Membranes and Organelles (R.E. Dalbey, Ed.) 4, pp. 129-144, JAI Press, Inc. (Review)

Ujwal, M.L., Jung, H., Bibi, E., Manoil, C., Altenbach, C., Hubbell, W. and Kaback, H.R. (1995) Membrane topology of helices VII and XI in the lactose permease of Escherichia coli studied by lacY-phoA fusion analysis and site-directed spectroscopy. Biochemistry 34, 14909-14917.

Jung, K., Jung, H. and Kaback H.R. (1994) Dynamics of lactose permease of Escherichia coli determined by site-directed fluorescence labeling. Biochemistry 33, 3980-3985.

Jung, H., Jung, K. and Kaback, H.R. (1994) A conformational change in the lactose permease of Escherichia coli is induced by ligand binding or membrane potential. Protein Sci. 3, 1053-1057.

Kaback, H.R., Frillingos, S., Jung, H., Jung, K., Privé, G.G., Ujwal, M.L., Weitzman, C., Wu, J. and Zen, K. (1994) The lactose permease meets Frankenstein. J. Exp. Biol. 196, 183-195. (Review)

Jung, H., Jung, K. and Kaback, H.R. (1994) Cysteine-148 of lactose permease of Escherichia coli is a component of a substrate binding site. I. Site-directed mutagenesis. Biochemistry 33, 12160-12165.

Roth, S., Jung, K., Jung, H., Hommel, R. and Kleber, H.-P. (1994) Crotonobetaine reductase from Escherichia coli - a new inducible enzyme of anaerobic metabolization of L(-)-carnitine. Antonie van Leeuwenhoek 65, 63-69.

Jung, K., Jung, H., Wu, J., Prive, G.G. and Kaback, H.R. (1993) Use of site-directed fluorescence labeling to study proximity relationships in the lactose permease of Escherichia coli. Biochemistry 32, 12273-12278.

Kaback, H.R., Jung, K., Jung, H., Wu, J. and Prive, G.G. (1993) What’s new with lactose permease. J. Bioenerg. Biomembr. 25, 627-635.

Jung, H., Jung, K. and Kleber, H.-P. (1992) Synthesis of L-carnitine by microorganisms and enzymes. Adv. Biochem. Eng. Biotechnol. 50, 21-44. (Review)

Jung, H. and Kleber, H.-P. (1991) Metabolism of D(+)-carnitine by Escherichia coli. Appl. Microbiol. Biotechnol. 35, 393-395.

Jung, H., Jung, K. and Kleber, H.-P. (1990) L-Carnitine metabolization and osmotic stress response in Escherichia coli. J. Basic Microbiol. 30, 409-413.

Jung, H., Jung, K. and Kleber, H.-P. (1990) L-Carnitine uptake by Escherichia coli. J. Basic Microbiol. 30, 507-514.

Jung, H., Jung, K. and Kleber, H.-P. (1989) Purification and properties of carnitine dehydratase from Escherichia coli - a new enzyme of carnitine metabolization. Biochim. Biophys. Acta 1003, 270-276.

Jung, K., Jung, H. and Kleber, H.-P. (1987) Regulation of L-carnitine metabolism in Escherichia coli. J. Basic Microbiol. 27, 131-137.

Seim, H., Jung, H., Löster, H. and Kleber, H.-P. (1985) Wachstumsstimulation und Carnitinmetabolismus in Escherichia coli. Wiss. Z. Karl-Marx-Univ. Leipzig, Math.-Nat. R. 34, 287-292.

Patents

Jung, H., Jung, K. and Kleber, H.-P. Verfahren zur enzymatischen Synthese von L(-)-Carnitin DD281735 (PUB 29.08.1990); EP0320460 (PUB 14.06.1989); US4906586 (PUB 06.03.1990); JP1144996 (PUB 07.06.1989)

Jung, H., Jung, K., and Kleber, H.P. Verfahren zur Herstellung eines Enzyms DD281919 (PUB 29.08.1990)

Jung, H. and Kleber, H.P. Verfahren zur Herstellung von L(-)-Carnitin aus D(+)-Carnitin DD3213126